Abstract
Signaling through the highly conserved Wingless/Wnt pathway plays a crucial role in a diverse array of developmental processes, many of which depend upon the precise regulation of Wingless/Wnt signaling levels. Recent evidence has indicated that the intracellular trafficking of Wingless/Wnt signaling components can result in significant changes in the level of signaling. Here, we examine three mechanisms through which intracellular trafficking might regulate Wingless signaling--the degradation of Wingless, its transport and the transduction of its signal. The intracellular trafficking of several Wingless/Wnt signaling components, including LRP5, LRP6, Dishevelled and Axin, as well as the functional implications of protein localization on Wingless/Wnt signaling, will be discussed.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Adaptor Proteins, Signal Transducing
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Animals
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Axin Protein
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Dishevelled Proteins
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Drosophila Proteins / metabolism*
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Humans
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LDL-Receptor Related Proteins
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Low Density Lipoprotein Receptor-Related Protein-5
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Low Density Lipoprotein Receptor-Related Protein-6
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Phosphoproteins / physiology
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Proto-Oncogene Proteins / metabolism*
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Receptors, LDL / physiology
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Repressor Proteins / physiology
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Signal Transduction*
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Wnt Proteins
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Wnt1 Protein
Substances
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Adaptor Proteins, Signal Transducing
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Axin Protein
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Dishevelled Proteins
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Drosophila Proteins
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LDL-Receptor Related Proteins
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LRP5 protein, human
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LRP6 protein, human
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Low Density Lipoprotein Receptor-Related Protein-5
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Low Density Lipoprotein Receptor-Related Protein-6
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Phosphoproteins
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Proto-Oncogene Proteins
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Receptors, LDL
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Repressor Proteins
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Wnt Proteins
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Wnt1 Protein
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dsh protein, Drosophila
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wg protein, Drosophila