Lens and retina regeneration: transdifferentiation, stem cells and clinical applications

Exp Eye Res. 2004 Feb;78(2):161-72. doi: 10.1016/j.exer.2003.10.022.


In this review we present a synthesis on the potential of vertebrate eye tissue regeneration, such as lens and retina. Particular emphasis is given to two different strategies used for regeneration, transdifferentiation and stem cells. Similarities and differences between these two strategies are outlined and it is proposed that both strategies might follow common pathways. Furthermore, we elaborate on specific clinical applications as the outcome of regeneration-based research.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Differentiation / physiology
  • Disease Models, Animal
  • Humans
  • Lens, Crystalline / physiology*
  • Regeneration*
  • Retina / physiology*
  • Stem Cell Transplantation
  • Stem Cells / cytology*