Lens regeneration in mice: implications in cataracts

Exp Eye Res. 2004 Feb;78(2):297-9. doi: 10.1016/j.exer.2003.10.021.


Lens regeneration in adult mice is possible when the lens capsule is left behind after lentectomy. The lens is regenerated by the remaining adherent lens epithelial cells, which differentiate to form lens fibres within days, showing normal morphology and bow regions. Epithelial to mesenchymal cell transformation is also seen during the early stages. The mouse, therefore, can become an indispensable animal model for cataract research, surgery and therapy.

Publication types

  • Letter
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cataract / physiopathology*
  • Cataract Extraction
  • Disease Models, Animal
  • Female
  • Lens, Crystalline / physiology*
  • Male
  • Mice
  • Mice, Inbred Strains
  • Regeneration*