Mouse models to study G-protein-mediated signaling

Pharmacol Ther. 2004 Jan;101(1):75-89. doi: 10.1016/j.pharmthera.2003.10.005.


The G-protein-mediated signaling system has evolved as one of the most widely used transmembrane signaling mechanisms in eukaryotic organisms. Mammalian cells express many G-protein-coupled receptors as well as several types of heterotrimeric G-proteins and effectors. This review focuses on recent data from studies in mutant mice, which have elucidated some of the roles of G-protein-mediated signaling in physiology and pathophysiology.

Publication types

  • Review

MeSH terms

  • Animals
  • Cardiovascular Physiological Phenomena
  • Endocrine System / physiology
  • GTP-Binding Proteins / physiology*
  • Immune System / physiology
  • Mice
  • Mice, Knockout
  • Models, Animal
  • Nervous System Physiological Phenomena
  • Receptors, G-Protein-Coupled / physiology
  • Signal Transduction / physiology


  • Receptors, G-Protein-Coupled
  • GTP-Binding Proteins