The Caenorhabditis elegans homolog of the putative prostate cancer susceptibility gene ELAC2, hoe-1, plays a role in germline proliferation

Dev Biol. 2004 Feb 1;266(1):151-60. doi: 10.1016/j.ydbio.2003.10.016.


The potential prostate cancer susceptibility gene ELAC2 has a Caenorhabditis elegans homolog (which we call hoe-1, for homolog of ELAC2). We have explored the biological role of this gene using RNAi to reduce gene activity. We found that worms subjected to hoe-1 RNAi are slow-growing and sterile. The sterility results from a drastic reduction in germline proliferation and cell-cycle arrest of germline nuclei. We found that hoe-1 is required for hyperproliferation phenotypes seen with mutations in three different genes, suggesting hoe-1 may be generally required for germline proliferation. We also found that reduction of hoe-1 by RNAi suppresses the multivulva (Muv) phenotype resulting from activating mutations in ras and that this suppression is likely to be indirect. This is the first demonstration of a biological role for this class of proteins in a complex eukaryote and adds important information when considering the role of ELAC2 in prostate cancer.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Caenorhabditis elegans / genetics*
  • Caenorhabditis elegans Proteins
  • DNA, Complementary
  • Genetic Predisposition to Disease*
  • Germ Cells*
  • Male
  • Molecular Sequence Data
  • Neoplasm Proteins / genetics*
  • Phenotype
  • Polymerase Chain Reaction
  • Prostatic Neoplasms / genetics*
  • Prostatic Neoplasms / pathology
  • RNA / genetics


  • Caenorhabditis elegans Proteins
  • DNA, Complementary
  • Neoplasm Proteins
  • hoe-1 protein, C elegans
  • RNA