Suppression by Hydrangeae Dulcis Folium of D-galactosamine-induced liver injury in vitro and in vivo

Biosci Biotechnol Biochem. 2003 Dec;67(12):2641-3. doi: 10.1271/bbb.67.2641.


Hydrangeae Dulcis Folium, the fermented and dried leaves of Hydrangea macrophylla SER. var. thunbergii MAKINO, suppressed D-galactosamine-induced liver injury by 85.2% when added to the diet at 1% and fed to rats for fifteen days. The hepatoprotective effect is more potent than that of a milk thistle extract and turmeric powder. Some fractionated extracts showed hepatoprotective activity in the D-galactosamine-induced in vitro liver injury model.

MeSH terms

  • Alanine Transaminase / analysis*
  • Alanine Transaminase / blood
  • Animals
  • Chemical and Drug Induced Liver Injury
  • Galactosamine / toxicity
  • Hydrangea / chemistry*
  • Liver / drug effects*
  • Liver / injuries
  • Liver Diseases / drug therapy*
  • Phytotherapy*
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Rats
  • Rats, Wistar


  • Plant Extracts
  • Galactosamine
  • Alanine Transaminase