Profilin as a potential mediator of membrane-cytoskeleton communication

Trends Cell Biol. 1993 Nov;3(11):381-5. doi: 10.1016/0962-8924(93)90087-h.


Profilin, the prototype actin-monomer-sequestering protein, has recently emerged as a multifunctional protein with several different activities. Genetic evidence in yeast and flies confirms that profilin is required for a normal actin cytoskeleton, while biochemical evidence suggests a role in regulating phosphoinositide signalling. New studies suggest that profilin may interact with other ligands, and even its role in regulating actin polymerization is now being re-evaluated.