MAP kinase regulation--the oncogene connection

S J Leevers; C J Marshall

doi:10.1016/0962-8924(92)90105-v

MAP kinase regulation--the oncogene connection

Trends Cell Biol. 1992 Oct;2(10):283-6. doi: 10.1016/0962-8924(92)90105-v.

Authors

S J Leevers¹, C J Marshall

Affiliation

¹ Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London, UK SW3 6JB.

PMID: 14731911
DOI: 10.1016/0962-8924(92)90105-v

Abstract

The mitogen-activated protein kinase (MAP kinase) family of cytoplasmic serine/threonine protein kinases is activated by a wide range of extracellular stimuli. In this review we focus on the accumulating evidence that proteins encoded by proto-oncogenes and oncogenes are either involved in the regulation of the MAP kinase pathway or are its targets.