Developmental expression of brain derived neurotrophic factor mRNA by neurons of fetal and adult monkey prefrontal cortex

Brain Res Dev Brain Res. 1992 Nov 20;70(1):53-63. doi: 10.1016/0165-3806(92)90103-4.


In situ hybridization histochemistry with labeled cRNA probes complementary to monkey brain derived neurotrophic factor (BDNF) mRNAs has been used to study the cellular localization and expression of this neurotrophin in the prefrontal cerebral cortex of fetal and adult monkeys. Expression could not be detected in prefrontal cortex before the 121st fetal day. Thereafter, in fetal life and in adulthood BDNF mRNA could be detected primarily in large, putative pyramidal cells of layers III and VI throughout the prefrontal cortex. The temporal course and cellular localization of BDNF expression suggests its association with the development and stabilization of specific connections in regions of cortex that display marked functional plasticity.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aging / physiology*
  • Animals
  • Brain-Derived Neurotrophic Factor
  • Cerebral Cortex / embryology
  • Cerebral Cortex / growth & development
  • Cerebral Cortex / physiology*
  • Embryonic and Fetal Development
  • Frontal Lobe / physiology
  • Gestational Age
  • In Situ Hybridization
  • Macaca mulatta
  • Nerve Growth Factors / biosynthesis*
  • Nerve Growth Factors / genetics
  • Nerve Tissue Proteins / biosynthesis*
  • Nerve Tissue Proteins / genetics
  • Neurons / physiology*
  • RNA Probes
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism*


  • Brain-Derived Neurotrophic Factor
  • Nerve Growth Factors
  • Nerve Tissue Proteins
  • RNA Probes
  • RNA, Messenger