FGF-23 Transgenic Mice Demonstrate Hypophosphatemic Rickets With Reduced Expression of Sodium Phosphate Cotransporter Type IIa

Biochem Biophys Res Commun. 2004 Feb 6;314(2):409-14. doi: 10.1016/j.bbrc.2003.12.102.

Abstract

Fibroblast growth factor (FGF)-23 was identified as a causative factor of tumor-induced osteomalacia and also as a responsible gene for autosomal dominant hypophosphatemic rickets. To clarify the pathophysiological roles of FGF-23 in these diseases, we generated its transgenic mice. The transgenic mice expressing human FGF-23 reproduced the common clinical features of these diseases such as hypophosphatemia probably due to increased renal phosphate wasting, inappropriately low serum 1,25-dihydroxyvitamin D level, and rachitic bone. The renal phosphate wasting in the transgenic mice was accompanied by the reduced expression of sodium phosphate cotransporter type IIa in renal proximal tubules. These results reinforce the notion that the excessive action of FGF-23 plays a causative role in the development of several hypophosphatemic rickets/osteomalacia.

MeSH terms

  • Animals
  • Animals, Newborn
  • Bone and Bones / diagnostic imaging
  • Fibroblast Growth Factors / genetics*
  • Fibroblast Growth Factors / physiology*
  • Humans
  • Immunohistochemistry
  • Kidney Tubules / metabolism
  • Mice
  • Mice, Transgenic
  • Plasmids / metabolism
  • Radiography
  • Reverse Transcriptase Polymerase Chain Reaction
  • Rickets / genetics*
  • Sodium-Phosphate Cotransporter Proteins
  • Sodium-Phosphate Cotransporter Proteins, Type IIa
  • Symporters / biosynthesis
  • Symporters / genetics*
  • Time Factors
  • Tissue Distribution
  • Transgenes
  • Vitamin D / analogs & derivatives*
  • Vitamin D / blood

Substances

  • SLC34A1 protein, human
  • Slc34a1 protein, mouse
  • Sodium-Phosphate Cotransporter Proteins
  • Sodium-Phosphate Cotransporter Proteins, Type IIa
  • Symporters
  • Vitamin D
  • Fibroblast Growth Factors
  • 1,25-dihydroxyvitamin D
  • fibroblast growth factor 23