MHC class II signaling in antigen-presenting cells

Curr Opin Immunol. 2004 Feb;16(1):108-13. doi: 10.1016/j.coi.2003.11.006.


The MHC class II molecules have been recognized as signaling receptors for more than a decade, and recent work has revealed the importance of their signaling for the immune response. Today, we know that the function of MHC class II molecules on antigen-presenting cells (APCs) is not limited to their role as antigen-presenting structures; they are flexible receptors that, by triggering a variety of signaling pathways, can regulate APC activities from proliferation and maturation to apoptosis. Recent advances have provided insights into how these molecules might accommodate such regulation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigen Presentation*
  • Antigen-Presenting Cells / immunology*
  • B-Lymphocytes / immunology
  • Histocompatibility Antigens Class II / physiology*
  • Membrane Microdomains / physiology
  • Protein Kinase C / physiology
  • Protein-Tyrosine Kinases / physiology
  • Receptors, Antigen / physiology
  • Signal Transduction*
  • T-Lymphocytes / immunology


  • Histocompatibility Antigens Class II
  • Receptors, Antigen
  • Protein-Tyrosine Kinases
  • Protein Kinase C