Conferring specificity on the ubiquitous Raf/MEK signalling pathway

Br J Cancer. 2004 Jan 26;90(2):283-8. doi: 10.1038/sj.bjc.6601488.


The Raf-MEK-ERK signalling pathway controls fundamental cellular processes including proliferation, differentiation and survival. It remains enigmatic how this pathway can reliably convert a myriad of extracellular stimuli in specific biological responses. Recent results have shown that the Raf family isoforms A-Raf, B-Raf and Raf-1 have different physiological functions. Here we review how Raf isozyme diversity contributes to the specification of functional diversity, in particular regarding the role of Raf isozymes in cancer.

Publication types

  • Review

MeSH terms

  • Cell Differentiation
  • Cell Survival
  • Humans
  • Isoenzymes
  • MAP Kinase Kinase Kinase 1*
  • MAP Kinase Kinase Kinases / genetics*
  • MAP Kinase Kinase Kinases / pharmacology*
  • Neoplasms / physiopathology*
  • Proto-Oncogene Proteins c-raf / genetics*
  • Proto-Oncogene Proteins c-raf / pharmacology*
  • Signal Transduction*


  • Isoenzymes
  • Proto-Oncogene Proteins c-raf
  • MAP Kinase Kinase Kinase 1
  • MAP Kinase Kinase Kinases
  • MAP3K1 protein, human