Mammalian small molecule methyltransferases: their structural and functional features

Int J Biochem. 1992 Dec;24(12):1917-24. doi: 10.1016/0020-711x(92)90287-b.

Abstract

Structural and functional features of mammalian S-adenosyl-methionine-dependent small molecule methyltransferases are reviewed. The methyltransferases have similar protomer molecular weights in the range of 25,000-35,000. Two common sequence motifs are found in all enzymes of known sequence. Whereas the kinetic mechanisms may be different, the methyltransferases in the free form bind S-adenosylmethionine. Most, if not all, of mammalian small molecule methyltransferases appear to have vicinal thiols in a catalytically important area of the enzyme.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Humans
  • Methyltransferases / chemistry
  • Methyltransferases / metabolism*
  • Molecular Sequence Data
  • S-Adenosylmethionine / metabolism
  • Sequence Homology, Amino Acid

Substances

  • S-Adenosylmethionine
  • Methyltransferases