Synthesis of an S-linked glycopeptide analog derived from human Tamm-Horsfall glycoprotein

Org Biomol Chem. 2004 Jan 7;2(1):31-3. doi: 10.1039/b311583f. Epub 2003 Nov 18.

Abstract

Direct base catalyzed S-glycosylation of a cysteine and a homocysteine containing peptide with O-acetyl protected bromides in DMF-water solution furnished two glycopeptide fragments. The two glycopeptide fragments were linked to the target glycopeptide with two S-glycosyl residues mimicking a part of Tamm-Horsfall glycoprotein.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cysteine / chemistry
  • Glycopeptides / chemical synthesis*
  • Glycopeptides / chemistry
  • Humans
  • Mucoproteins / chemistry
  • Uromodulin

Substances

  • Glycopeptides
  • Mucoproteins
  • UMOD protein, human
  • Uromodulin
  • Cysteine