Toxicokinetics of cinnamaldehyde in F344 rats

Food Chem Toxicol. 1992 Dec;30(12):997-1004. doi: 10.1016/0278-6915(92)90109-x.

Abstract

The toxicokinetic profile of cinnamaldehyde (CNMA) was investigated in Fischer 344 rats. CNMA was found to be unstable in blood. After iv administration, a large fraction of CNMA was immediately oxidized to cinnamic acid. The biological half-life of CNMA after iv administration was found to be 1.7 hr. After administration by gavage of CNMA at 250 or 500 mg/kg body weight using corn oil as vehicle, the maximum blood concentrations of CNMA were in the order of 1 microgram/ml. These low blood concentrations were maintained over a 24-hr period after a dose of 500 mg/kg, which is relatively long considering the short (1.7 hr) biological half-life of CNMA. The estimated oral bioavailability of CNMA was less than 20% for both the 250 and 500 mg/kg doses. No CNMA was present in blood at any time in rats dosed with 50 mg CNMA/kg body weight. Only a small amount of the administered CNMA was excreted in rat urine as free cinnamic acid or beta-glucuronide-conjugated cinnamic acid. The majority of CNMA administered orally was excreted in urine as hippuric acid within 24 hr. The maximum excretion rate occurred at 8 hr after gavage. Hippuric acid recovered in 50-hr urine samples was found to be directly proportional to the oral dose of CNMA.

MeSH terms

  • Acrolein / analogs & derivatives*
  • Acrolein / blood
  • Acrolein / pharmacokinetics
  • Acrolein / toxicity
  • Administration, Oral
  • Animals
  • Biological Availability
  • Cinnamates / urine
  • Female
  • Half-Life
  • Hippurates / urine
  • Injections, Intravenous
  • Male
  • Rats
  • Rats, Inbred F344

Substances

  • Cinnamates
  • Hippurates
  • Acrolein
  • cinnamic aldehyde
  • hippuric acid
  • cinnamic acid