Necrolytic migratory erythema: case report and clinical review

J Cutan Med Surg. 2003 Jul-Aug;7(4):333-8. doi: 10.1007/s10227-002-0127-0.


Background: Necrolytic Migratory Erythema (NME) is a rarely encountered dermatologic condition. It is the characteristic feature of a paraneoplastic syndrome associated with neuroendocrine pancreatic tumors. A case of NME initially diagnosed and treated as psoriasis is reviewed. A review of the current literature regarding NME is also included.

Objective: The purpose of this report is to familiarize dermatologists with a rare and potentially fatal disorder. Early recognition of NME can lead to possible cure, while delayed identification of the disease is associated with metastatic disease and a poor prognosis for the patient.

Conclusion: When evaluating the patient who presents with a dermatitis and weight loss, it is important to exercise great caution. The differential diagnosis should be re-evaluated in a disease that is not responsive to first-line therapy before further treatment is considered.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Antineoplastic Agents, Hormonal / therapeutic use
  • Erythema / drug therapy*
  • Erythema / etiology
  • Glucagonoma / complications*
  • Glucagonoma / diagnostic imaging
  • Humans
  • Male
  • Octreotide / therapeutic use
  • Pancreatic Neoplasms / complications*
  • Pancreatic Neoplasms / diagnostic imaging
  • Paraneoplastic Syndromes / drug therapy*
  • Paraneoplastic Syndromes / etiology
  • Radiography
  • Treatment Outcome


  • Antineoplastic Agents, Hormonal
  • Octreotide