Recombination: Holliday Junction Resolution and Crossover Formation

Curr Biol. 2004 Jan 20;14(2):R56-8. doi: 10.1016/j.cub.2003.12.043.

Abstract

The heterodimeric nuclease Mus81-Eme1 has been proposed to be a Holliday junction resolvase and has now been found to be responsible for nearly all meiotic crossovers in fission yeast. The intriguing substrate preference of this enzyme for nicked Holliday junctions opens the possibility that crossover formation may not always involve double Holliday junctions.

Publication types

  • Review

MeSH terms

  • Crossing Over, Genetic / genetics*
  • DNA Damage / genetics
  • DNA Damage / physiology
  • DNA Repair / genetics
  • DNA Repair / physiology
  • DNA-Binding Proteins / genetics*
  • DNA-Binding Proteins / metabolism
  • Endonucleases*
  • Holliday Junction Resolvases / genetics*
  • Meiosis / genetics
  • Meiosis / physiology*
  • Models, Genetic*
  • Saccharomyces cerevisiae Proteins
  • Schizosaccharomyces

Substances

  • DNA-Binding Proteins
  • Saccharomyces cerevisiae Proteins
  • Endonucleases
  • MUS81 protein, S cerevisiae
  • Holliday Junction Resolvases