Abstract
In early C. elegans embryos, the transition from meiosis to mitosis requires degradation of the MEI-1 protein. A novel class of SCF-like ubiquitin ligases has been identified that mediates this process. These ligases contain the CUL-3 scaffold at their core and use a BTB-domain protein in substrate recognition.
MeSH terms
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Adenosine Triphosphatases / metabolism*
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Animals
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Caenorhabditis elegans
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Caenorhabditis elegans Proteins / metabolism*
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Embryo, Nonmammalian
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Meiosis / physiology
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Mitosis / physiology
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Models, Molecular*
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Peptide Hydrolases / metabolism*
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Peptide Hydrolases / physiology
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SKP Cullin F-Box Protein Ligases / metabolism*
Substances
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Caenorhabditis elegans Proteins
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SKP Cullin F-Box Protein Ligases
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Peptide Hydrolases
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Adenosine Triphosphatases
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MEI-1 protein, C elegans