Protein degradation: CUL-3 and BTB--partners in proteolysis

Curr Biol. 2004 Jan 20;14(2):R59-61.

Abstract

In early C. elegans embryos, the transition from meiosis to mitosis requires degradation of the MEI-1 protein. A novel class of SCF-like ubiquitin ligases has been identified that mediates this process. These ligases contain the CUL-3 scaffold at their core and use a BTB-domain protein in substrate recognition.

Publication types

  • Review

MeSH terms

  • Adenosine Triphosphatases / metabolism*
  • Animals
  • Caenorhabditis elegans
  • Caenorhabditis elegans Proteins / metabolism*
  • Embryo, Nonmammalian
  • Meiosis / physiology
  • Mitosis / physiology
  • Models, Molecular*
  • Peptide Hydrolases / metabolism*
  • Peptide Hydrolases / physiology
  • SKP Cullin F-Box Protein Ligases / metabolism*

Substances

  • Caenorhabditis elegans Proteins
  • SKP Cullin F-Box Protein Ligases
  • Peptide Hydrolases
  • Adenosine Triphosphatases
  • MEI-1 protein, C elegans