Relationship between serum adiponectin and leptin concentrations and body fat distribution

Diabetes Res Clin Pract. 2004 Feb;63(2):135-42. doi: 10.1016/j.diabres.2003.09.010.


The aim of this study was to investigate the relationship between adiponectin and leptin and body fat distribution. One hundred and ninety-seven women participated in this study. Subjects were grouped based on their visceral adipose tissue area (VAT). Body fat distribution was determined by computed tomography. The numbers in the subcutaneous fat dominant group (SFDG) and visceral fat dominant group (VFDG) were 79 and 118, respectively. The VFDG showed lower adiponectin levels than the SFDG (8.9+/-0.4 microg/ml versus 11.4+/-0.7 microg/ml, P=0.006), but leptin levels did not differ significantly between groups (18.8+/-1.1 ng/ml versus 17.7+/-1.8 ng/ml, P=0.111). Adiponectin levels were inversely correlated with fasting insulin, HOMA-IR, triglyceride, SBP and DBP, subcutaneous adipose tissue area (SAT) and VAT, and waist-to-hip ratio (WHR). Leptin levels were positively correlated with fasting glucose and insulin, HOMA-IR, triglyceride, SBP and DBP, VAT and SAT, and WHR (all values of P<0.05). VAT and HDL-cholesterol were independent variables of adiponectin concentrations (R(2)=0.207, P<0.0001), and SAT, fasting insulin, and HOMA-IR were independent variables of leptin concentrations (R(2)=0.498, P<0.0001) In conclusion, adiponectin and leptin concentrations, although associated with metabolic parameters, were more strongly influenced by VAT in the case of adiponectin, and by SAT in the case of leptin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adiponectin
  • Adipose Tissue*
  • Adolescent
  • Adult
  • Aged
  • Blood Glucose / analysis
  • Body Composition*
  • Body Constitution
  • Cholesterol / blood
  • Cholesterol, HDL / blood
  • Cholesterol, LDL / blood
  • Fasting
  • Female
  • Homeostasis
  • Humans
  • Insulin / blood
  • Insulin Resistance
  • Intercellular Signaling Peptides and Proteins*
  • Leptin / blood*
  • Linear Models
  • Middle Aged
  • Proteins / analysis*
  • Tomography, X-Ray Computed
  • Triglycerides / blood
  • Viscera


  • Adiponectin
  • Blood Glucose
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Insulin
  • Intercellular Signaling Peptides and Proteins
  • Leptin
  • Proteins
  • Triglycerides
  • Cholesterol