Possible association between Cys311Ser polymorphism of paraoxonase 2 gene and late-onset Alzheimer's disease in Chinese

Brain Res Mol Brain Res. 2004 Jan 5;120(2):201-4. doi: 10.1016/j.molbrainres.2003.10.018.

Abstract

The common polymorphism at codon 311 (C311S) of paraoxonase 2 gene (PON2) was investigated in 165 patients with sporadic late-onset Alzheimer's disease (LOAD) and 174 controls in Chinese. The PON2*C allele frequency was significantly increased in the patients as compared with controls. However, no significant difference was observed after stratification of apolipoprotein E (ApoE) epsilon4 allele. These results suggested that the PON2 polymorphism might be a risk factor for LOAD independent of ApoE epsilon4 status in Chinese.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alleles
  • Alzheimer Disease / genetics*
  • Apolipoproteins E / genetics
  • Aryldialkylphosphatase / genetics*
  • Aryldialkylphosphatase / metabolism
  • Asian Continental Ancestry Group / genetics*
  • Chi-Square Distribution
  • Cysteine / genetics
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease*
  • Genotype
  • Humans
  • Male
  • Polymerase Chain Reaction / methods
  • Polymorphism, Genetic*
  • Serine / genetics

Substances

  • Apolipoproteins E
  • Serine
  • Aryldialkylphosphatase
  • PON2 protein, human
  • Cysteine