Occurrence of melanoma in "dysplastic" nevus spilus: report of case and analysis by flow cytometry

J Cutan Pathol. 1992 Oct;19(5):423-8. doi: 10.1111/j.1600-0560.1992.tb00615.x.


We report a case of melanoma arising in a large nevus spilus. On histologic examination, the nevus spilus had diagnostic features of melanocytic dysplasia. Further characterization by flow cytometry showed DNA-aneuploidy within the melanoma as well as in one of the darker pigmented papules within the nevus spilus. The significance of this finding and a review of melanomas originating in nevi spili are presented.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Aged
  • Dysplastic Nevus Syndrome / complications*
  • Dysplastic Nevus Syndrome / pathology*
  • Female
  • Flow Cytometry
  • Humans
  • Male
  • Melanoma / complications*
  • Melanoma / pathology*
  • Middle Aged
  • Skin Neoplasms / complications*
  • Skin Neoplasms / pathology*