Ribosomal alterations contribute to bacterial resistance against the dipeptide antibiotic TAN 1057

E Limburg; R Gahlmann; H-P Kroll; D Beyer

doi:10.1128/AAC.48.2.619-622.2004

Ribosomal alterations contribute to bacterial resistance against the dipeptide antibiotic TAN 1057

Antimicrob Agents Chemother. 2004 Feb;48(2):619-22. doi: 10.1128/AAC.48.2.619-622.2004.

Authors

E Limburg¹, R Gahlmann, H-P Kroll, D Beyer

Affiliation

¹ Department of Antiinfectives, Pharma Research, Bayer Health Care AG, D-42096 Wuppertal, Germany.

Abstract

TAN 1057-resistant Staphylococcus aureus and Escherichia coli strains were selected to elucidate the mechanism of resistance and the mode of action of this dipeptide antibiotic. Cell-free translation with isolated ribosomes and S150 fractions from sensitive and resistant S. aureus strains demonstrated that alterations in the ribosomes contribute to the resistance of the bacteria.

MeSH terms

Anti-Bacterial Agents / pharmacology*
Dipeptides / pharmacology*
Drug Resistance, Bacterial
Erythromycin / pharmacology
Escherichia coli / drug effects*
Escherichia coli / genetics*
Microbial Sensitivity Tests
Protein Biosynthesis
Ribosomes / drug effects*
Ribosomes / genetics*
Staphylococcus aureus / drug effects*
Staphylococcus aureus / genetics*

Substances

Anti-Bacterial Agents
Dipeptides
TAN 1057A
Erythromycin