Periodontal disease and biomarkers related to cardiovascular disease

J Dent Res. 2004 Feb;83(2):151-5. doi: 10.1177/154405910408300213.


Periodontal disease is a chronic infection of the gums characterized by a loss of attachment between the tooth and bone, and by bone loss. We evaluated cross-sectionally the association between periodontal disease and C-reactive protein (CRP), fibrinogen, factor VII, tissue plasminogen activator (t-PA), LDL-C, von Willebrand factor, and soluble tumor necrosis factor receptors 1 and 2. The final sample consisted of 468 men (ages 47-80 yrs), participating in the Health Professional Follow-up Study, who provided blood and were free of CVD, diabetes, and cancer. In multivariate regression models controlling for age, cigarette smoking, alcohol intake, physical activity, and aspirin intake, self-reported periodontal disease was associated with significantly higher levels of CRP (30% higher among periodontal cases compared with non-cases), t-PA (11% higher), and LDL-C (11% higher). Based on our data, periodontal disease showed significant associations with biomarkers of endothelial dysfunction and dyslipidemia, which may potentially mediate the association between periodontal and cardiovascular disease.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Alcohol Drinking
  • Antigens, CD / blood
  • Aspirin / therapeutic use
  • Biomarkers / blood*
  • C-Reactive Protein / analysis
  • Cardiovascular Diseases / blood*
  • Cholesterol, LDL / blood
  • Cohort Studies
  • Cross-Sectional Studies
  • Factor VII / analysis
  • Fibrinogen / analysis
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Motor Activity
  • Periodontal Diseases / blood*
  • Platelet Aggregation Inhibitors / therapeutic use
  • Receptors, Tumor Necrosis Factor / blood
  • Receptors, Tumor Necrosis Factor, Type I
  • Receptors, Tumor Necrosis Factor, Type II
  • Smoking
  • Tissue Plasminogen Activator / blood
  • von Willebrand Factor / analysis


  • Antigens, CD
  • Biomarkers
  • Cholesterol, LDL
  • Platelet Aggregation Inhibitors
  • Receptors, Tumor Necrosis Factor
  • Receptors, Tumor Necrosis Factor, Type I
  • Receptors, Tumor Necrosis Factor, Type II
  • von Willebrand Factor
  • Factor VII
  • Fibrinogen
  • C-Reactive Protein
  • Tissue Plasminogen Activator
  • Aspirin