[Regulating effect of pineal gland peptides on development of T-lymphocytes in CBA aging mice: role of microenvironment of immune system organs and neuroendocrine factors]

Adv Gerontol. 2003:12:111-20.
[Article in Russian]


Studies were undertaken on the development of T-lymphocytes in adult and old CBA mice and its changes at aging after injections of pineal gland peptides. It was shown that in old mice the disturbances of T-cells differentiation are registered in bone marrow, thymus, spleen and characterized by the changes of lymphocyte markers expression, migration and proliferation of cells. In old mice FTS titer, melatonin and testosterone levels decreased, the balance of noradrenalin and serotonin in hypothalamus and the cell composition of microenvironment immune systems organs impaired. After chronic (18 mo) administration of the pineal gland preparation epithalamin the amount of stromal cells-precursors, CD4+ and Mac-1(+)-cells in old bone marrow increased, improved the migration of T-cell precursors from bone marrow to thymus and their proliferative potential. The proportion of CD3+, CD4+CD8-, CD4-CD8+, Mac-1(+)-cells in old thymus increased, while that of CD44(+)-cells decreased. The proportion of CD4-CD8(+)-cells in spleen increased. The most number of indices and their balance showed a pattern of adult mice. In old mice after epithalamin the balance of amines in hypothalamus improved, concentration of melatonin in pineal gland, testosterone and FTS titer in blood increased. Epithalon has also the possibility to increase of thymic endocrine function.

Publication types

  • English Abstract

MeSH terms

  • Aging / immunology*
  • Animals
  • Biogenic Monoamines / metabolism
  • Bone Marrow / immunology
  • Bone Marrow / physiology
  • Cell Differentiation / drug effects
  • Cell Differentiation / immunology
  • Cell Division / drug effects
  • Cell Division / immunology
  • Cell Movement / drug effects
  • Cell Movement / immunology
  • Immune System / immunology
  • Immune System / physiology*
  • Injections, Subcutaneous
  • Male
  • Melatonin / metabolism
  • Mice
  • Mice, Inbred CBA
  • Neurosecretory Systems / metabolism
  • Neurosecretory Systems / physiology
  • Oligopeptides / pharmacology*
  • Peptides / pharmacology*
  • Pineal Gland / metabolism
  • Pineal Gland / physiology*
  • Spleen / immunology
  • Spleen / physiology
  • T-Lymphocytes / cytology
  • T-Lymphocytes / drug effects*
  • T-Lymphocytes / immunology
  • Thymus Gland / immunology
  • Thymus Gland / physiology


  • Biogenic Monoamines
  • Oligopeptides
  • Peptides
  • epithalamin
  • Melatonin
  • alanyl-glutamyl-aspartyl-glycine