[Combined effect of vilon and cyclophosphane on tumor transplants and lymphoid tissue explants in mice and rats of various age]

Adv Gerontol. 2003;12:128-31.
[Article in Russian]


The experiments were performed in mice with transplanted Lewis lung carcinoma. The injections of synthetic peptide vilon at the doses 1 mg/kg significantly increased the survival of mice. So vilon has possessed the oncomodulating action on the transplanted carcinoma. The synchronous injection both of vilon and cyclophosphan at the doses 100 mg/kg decreases the survival of mice. There was also studied in spleen organotypic tissue culture the effect of vilon and cyclophosphan on the development of explants of rats of various age: 1 day and 2 years old. Vilon stimulated apoptosis both in young and old rats, but the inhibitory effect of cyclophosphan was abolished in the presence of vilon in culture media at the dose 5 ng/ml. The results obtained suggested that perspective preparates in the cancer therapy--vilon and cytostatic drugs-, must be used not synchronously.

MeSH terms

  • Aging / pathology*
  • Animals
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Carcinoma, Lewis Lung / drug therapy*
  • Carcinoma, Lewis Lung / pathology
  • Culture Media
  • Cyclophosphamide / administration & dosage
  • Cyclophosphamide / antagonists & inhibitors
  • Dipeptides / administration & dosage
  • Dipeptides / pharmacology
  • Drug Antagonism
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Neoplasm Transplantation
  • Organ Culture Techniques
  • Rats
  • Spleen / drug effects*


  • Culture Media
  • Dipeptides
  • Cyclophosphamide
  • lysylglutamic acid