Sample size calculations for the log rank test: a Gompertz model approach

J Clin Epidemiol. 1992 Oct;45(10):1131-6. doi: 10.1016/0895-4356(92)90153-e.

Abstract

Sample size calculations for clinical trials dealing with survivorship are often based on an exponential model. This model is inappropriate when a non-zero proportion of the population is expected to have indefinite survival. In such cases the Gompertz model offers a reasonable alternative. A method for calculating the required accrual time for a clinical trial in which the treatment arms have Gompertz survival distributions satisfying the proportion hazards assumption is developed. A computer program to perform this method is given, as well as an iterative method that can be used when a computer is not available.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Clinical Trials as Topic*
  • Humans
  • Models, Statistical
  • Survival Analysis*