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Review
, 116 (2), 153-66

The Mechanisms of Vesicle Budding and Fusion

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Review

The Mechanisms of Vesicle Budding and Fusion

Juan S Bonifacino et al. Cell.

Abstract

Genetic and biochemical analyses of the secretory pathway have produced a detailed picture of the molecular mechanisms involved in selective cargo transport between organelles. This transport occurs by means of vesicular intermediates that bud from a donor compartment and fuse with an acceptor compartment. Vesicle budding and cargo selection are mediated by protein coats, while vesicle targeting and fusion depend on a machinery that includes the SNARE proteins. Precise regulation of these two aspects of vesicular transport ensures efficient cargo transfer while preserving organelle identity.

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