Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2004 Jan 23;116(2):235-46.
doi: 10.1016/s0092-8674(03)01075-4.

Principles of Tumor Suppression

Affiliations
Free article
Review

Principles of Tumor Suppression

Charles J Sherr. Cell. .
Free article

Abstract

Molecular genetic studies of familial cancer syndromes identified and defined the recessive nature of tumor suppressor genes and resolved the paradox of why tumors arising in such families exhibited an autosomally dominant pattern of inheritance. Subsequent characterization of tumor suppressor proteins revealed their widespread involvement in sporadic cancers and pinpointed key mechanisms that protect animals against tumor development. We now recognize that tumor suppressor genes regulate diverse cellular activities, including cell cycle checkpoint responses, detection and repair of DNA damage, protein ubiquitination and degradation, mitogenic signaling, cell specification, differentiation and migration, and tumor angiogenesis. Their study has become a centerpiece of contemporary cancer research.

Similar articles

See all similar articles

Cited by 263 articles

See all "Cited by" articles

Publication types

LinkOut - more resources

Feedback