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Multicenter Study
. 2004 Feb 7;328(7435):326.
doi: 10.1136/bmj.37991.635266.44. Epub 2004 Jan 26.

Population based study of early risk of stroke after transient ischaemic attack or minor stroke: implications for public education and organisation of services

A J Coull  1 , J K Lovett, P M Rothwell; Oxford Vascular Study
Affiliations
Multicenter Study

Population based study of early risk of stroke after transient ischaemic attack or minor stroke: implications for public education and organisation of services

A J Coull et al. BMJ. .

Abstract

Objective: To estimate the very early stroke risk after a transient ischaemic attack (TIA) or minor stroke and thereby inform the planning of effective stroke prevention services.

Design: Population based prospective cohort study of patients with TIA or stroke.

Setting: Nine general practices in Oxfordshire, England, from April 2002 to April 2003.

Participants: All patients who had a TIA (n = 87) or minor stroke (n = 87) during the study period and who presented to medical attention.

Main outcome measures: Risk of recurrent stroke at seven days, one month, and three months after TIAs and minor strokes.

Results: The estimated risk of recurrent stroke was 8.0% (95% confidence interval 2.3% to 13.7%) at seven days, 11.5% (4.8% to 18.2%) at one month, and 17.3% (9.3% to 25.3%) at three months after a TIA. The risks at these three time periods after a minor stroke were 11.5% (4.8% to 11.2%), 15.0% (7.5% to 22.5%), and 18.5% (10.3% to 26.7%).

Conclusions: The early risks of stroke after a TIA or minor stroke are much higher than commonly quoted. More research is needed to determine whether these risks can be reduced by more rapid instigation of preventive treatment.

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Figures

Figure 1
Figure 1
Cumulative risk of stroke after a transient ischaemic attack (TIA) or minor stroke
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