Gadolinium-enhanced computed tomography angiography in multi-detector row computed tomography: initial observations

Acad Radiol. 2004 Jan;11(1):61-8. doi: 10.1016/s1076-6332(03)00536-1.

Abstract

Rationale and objectives: The feasibility of using gadolinium contrast medium for computed tomography angiography (CTA) in multi-detector row computed tomography and the effect of contrast medium dilution was investigated.

Materials and methods: Three pigs were each scanned in multiple sessions with injections of non-dilute and dilute contrast medium at a dose of 0.3 mmol/kg body weight. Non-spiral dynamic scanning at a fixed mid-abdominal aortic level and thoracoabdominal CTA were performed.

Results: The magnitude of peak aortic enhancement was not significantly different between dilute and non-dilute contrast medium injections (P = .88), but the former showed earlier enhancement (mean of 2.3 seconds sooner, P < .01) than the latter. CT angiography with gadolinium contrast medium showed much lower enhancement than iodine contrast medium, but small vessels were readily identifiable.

Conclusion: Gadolinium contrast medium combined with multi-detector row computed tomography may provide clinically useful CTA. Dilution of contrast medium shortens the enhancement time but has little effect on the magnitude.

Publication types

  • Comparative Study
  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiography
  • Animals
  • Contrast Media
  • Feasibility Studies
  • Gadolinium*
  • Injections, Intravenous
  • Iodine Radioisotopes
  • Models, Animal
  • Radiographic Image Enhancement
  • Radiographic Image Interpretation, Computer-Assisted
  • Radioisotopes*
  • Swine
  • Time Factors
  • Tomography, X-Ray Computed*

Substances

  • Contrast Media
  • Iodine Radioisotopes
  • Radioisotopes
  • Gadolinium