Serum proteomics in cancer diagnosis and management

Annu Rev Med. 2004;55:97-112. doi: 10.1146/


Mass spectrometry-based diagnostics has the potential to revolutionize molecular medicine. Using modern mass-spectrometer technologies, clinical tests can be developed that are practical, robust, accurate, and inexpensive. Serum proteomic pattern profiling couples mass spectrometry with adaptive artificial-intelligence-based bioinformatics, which can now be employed to detect pathological states reflected in the serum proteome. With this approach, rapid and cost-effective tests with exquisite clinical sensitivity and specificity are emerging. These tools may dramatically change how disease is detected, monitored, and managed.

Publication types

  • Review

MeSH terms

  • Blood Proteins / analysis
  • Blood Proteins / genetics*
  • Computational Biology
  • Humans
  • Mass Spectrometry
  • Neoplasms / diagnosis*
  • Neoplasms / genetics
  • Neoplasms / therapy*
  • Proteomics*


  • Blood Proteins