Left ventricular diastolic dysfunction and diastolic heart failure

Annu Rev Med. 2004;55:373-94. doi: 10.1146/annurev.med.55.091902.104417.


Thirty to fifty percent of patients presenting with signs and symptoms of heart failure have a normal left ventricular (LV) systolic ejection fraction. The clinical examination cannot distinguish these patients (diastolic heart failure) from those with a depressed ejection fraction (systolic heart failure), but echocardiography can. The management of diastolic heart failure has two major objectives. The first is to reverse the consequences of diastolic dysfunction (e.g., venous congestion), and the second is to eliminate or reduce the factors responsible for diastolic dysfunction (e.g., myocardial hypertrophy, fibrosis, and ischemia).

Publication types

  • Review

MeSH terms

  • Diastole / physiology*
  • Heart Failure / diagnosis*
  • Heart Failure / physiopathology*
  • Heart Failure / therapy
  • Humans
  • Ventricular Dysfunction, Left / diagnosis*
  • Ventricular Dysfunction, Left / physiopathology*
  • Ventricular Dysfunction, Left / therapy