Tamoxifen optic neuropathy

Clin Exp Ophthalmol. 2004 Feb;32(1):105-6. doi: 10.1046/j.1442-9071.2004.00769.x.


A 68-year-old woman with metastatic breast cancer presented with slowly progressive visual loss in each eye. Electrophysiology confirmed bilateral optic neuropathies. Investigations to determine the cause of the vision loss were negative. Cessation of tamoxifen resulted in a dramatic improvement in acuity.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Aged
  • Antineoplastic Agents, Hormonal / adverse effects*
  • Breast Neoplasms / drug therapy
  • Female
  • Humans
  • Optic Nerve Diseases / chemically induced*
  • Optic Nerve Diseases / physiopathology
  • Tamoxifen / adverse effects*
  • Visual Acuity / drug effects*
  • Visual Acuity / physiology
  • Visual Fields / drug effects


  • Antineoplastic Agents, Hormonal
  • Tamoxifen