Metabolic and stress responses of the body to trauma: produced by the laparoscopic and open cholecystectomy

Mymensingh Med J. 2004 Jan;13(1):48-52.


Laparoscopic cholecystectomy is regarded as gold standard therapy for symptomatic gall stone disease. This study was done to compare the metabolic and stress responses between open and lapraroscopic cholecystectomy and to evaluate their significance in postoperative recovery. Thirty patients with symptomatic gall stone disease were treated with open and laparoscopic cholecystectomy on elective basis (14 versus 16). Three samples of blood were collected from each patient to investigate serum cortisol, adrenaline, nor-adrenaline, C-reactive protein and blood glucose level. The mean age of patients was 41.86+/-10.13 blood glucose and stress hormones (cortisol, adrenaline, nor adrenaline) and C-reactive protein all were found significantly raised in the postoperative period in open cholecystectomy than laparoscopic cholecystectomy group. The postoperative recovery was also prolonged in the open group. The obvious clinical advantages of laparoscopic cholecystectomy over open cholecystectomy is mainly because of less metabolic and stress response.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Blood Glucose / analysis
  • Blood Glucose / metabolism
  • C-Reactive Protein / analysis
  • C-Reactive Protein / metabolism
  • Cholecystectomy / adverse effects*
  • Cholecystectomy / methods
  • Cholecystectomy, Laparoscopic / adverse effects*
  • Cholecystolithiasis / surgery*
  • Epinephrine / blood
  • Epinephrine / metabolism
  • Female
  • Humans
  • Hydrocortisone / blood
  • Hydrocortisone / metabolism
  • Male
  • Middle Aged
  • Norepinephrine / blood
  • Norepinephrine / metabolism
  • Pain, Postoperative / metabolism
  • Postoperative Complications / metabolism
  • Prospective Studies
  • Stress, Physiological / blood
  • Stress, Physiological / etiology
  • Stress, Physiological / metabolism*
  • Wounds and Injuries / blood
  • Wounds and Injuries / etiology
  • Wounds and Injuries / metabolism*


  • Blood Glucose
  • C-Reactive Protein
  • Hydrocortisone
  • Norepinephrine
  • Epinephrine