Vascular permeability factor mRNA and protein expression in human kidney

Kidney Int. 1992 Dec;42(6):1457-61. doi: 10.1038/ki.1992.441.

Abstract

Vascular permeability factor (VPF), also known as vascular endothelial growth factor (VEGF), is a potent microvascular permeability-enhancing mediator as well as a selective mitogen for vascular endothelium. In this study, in situ hybridization and immunohistochemistry co-localized VPF mRNA and protein to glomerular visceral epithelial cells in human kidneys. Northern analysis confirmed the presence of VPF mRNA of expected size. The finding of VPF in renal glomerular epithelium identifies a potent mediator of permeability and endothelial proliferation whose role in renal physiology and pathology requires investigation.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Capillary Permeability
  • Endothelial Growth Factors / genetics
  • Endothelial Growth Factors / metabolism*
  • Endothelium, Vascular / metabolism
  • Gene Expression
  • Humans
  • Immunohistochemistry
  • In Situ Hybridization
  • Kidney / metabolism*
  • Kidney Glomerulus / blood supply
  • Kidney Glomerulus / metabolism
  • Lymphokines / genetics
  • Lymphokines / metabolism*
  • Molecular Sequence Data
  • RNA Probes
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism*
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors

Substances

  • Endothelial Growth Factors
  • Lymphokines
  • RNA Probes
  • RNA, Messenger
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors