Contraction-induced oxidants as mediators of adaptation and damage in skeletal muscle

Exerc Sport Sci Rev. 2004 Jan;32(1):14-8. doi: 10.1097/00003677-200401000-00004.


Contracting skeletal muscle generates reactive oxygen and nitrogen species (ROS) that can induce changes in gene expression or cell damage depending upon the pattern of production and the endogenous protective systems. The hypothesis is presented that skeletal muscle uses contraction-induced ROS as signals to induce adaptive responses including maintenance of oxidant homeostasis and prevention of oxidative damage.

Publication types

  • Review

MeSH terms

  • Adaptation, Physiological
  • Biomarkers / analysis
  • Homeostasis
  • Humans
  • Muscle Contraction / physiology*
  • Muscle, Skeletal / injuries*
  • Muscle, Skeletal / metabolism*
  • Oxidation-Reduction
  • Reactive Nitrogen Species / metabolism
  • Reactive Oxygen Species / analysis
  • Reactive Oxygen Species / metabolism*
  • Sensitivity and Specificity
  • Signal Transduction


  • Biomarkers
  • Reactive Nitrogen Species
  • Reactive Oxygen Species