Membrane cholesterol and the regulation of signal transduction

Biochem Soc Trans. 2004 Feb;32(Pt 1):65-9. doi: 10.1042/bst0320065.


The plasma membrane of mammalian cells consists of microdomains differing in lipid and protein composition. Two distinct classes of cholesterol/sphingolipid microdomain (caveolae and lipid rafts) are assembly points for transmembrane signalling complexes. Recent evidence suggests that transient changes in cholesterol content may be important in regulating signal transduction.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Caveolae / chemistry
  • Caveolae / metabolism
  • Cholesterol / metabolism*
  • Homeostasis
  • Membrane Microdomains / chemistry*
  • Membrane Microdomains / metabolism*
  • Membrane Microdomains / virology
  • Signal Transduction*


  • Cholesterol