The genes and proteins of atherogenic lipoprotein production

Biochem Soc Trans. 2004 Feb;32(Pt 1):70-4. doi: 10.1042/bst0320070.

Abstract

Dietary fat provides a major source of nutrition, but may in excess lead to obesity, insulin resistance, high blood cholesterol levels and atherosclerosis. Here we report molecular events that co-ordinate whole-body lipid homoeostasis from insects to humans, viewed in the context of rare and common genetic disorders of apolipoprotein B-containing lipoprotein production.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Abetalipoproteinemia / genetics
  • Animals
  • Arteriosclerosis / genetics*
  • Arteriosclerosis / metabolism*
  • Carrier Proteins / genetics
  • Glycogen Storage Disease Type IV / genetics
  • Humans
  • Hyperlipidemias / genetics
  • Lipoproteins / biosynthesis*
  • Lipoproteins / metabolism

Substances

  • Carrier Proteins
  • Lipoproteins
  • lipid transfer protein