Risk modifiers for peripheral sensory neuropathy in HIV infection/AIDS

Eur J Neurol. 2004 Feb;11(2):97-102. doi: 10.1046/j.1351-5101.2003.00713.x.


The objective of this study is to examine the risk factors associated with the development of sensory neuropathy in human immunodeficiency virus (HIV)-infected patients in 292 HIV+ patients recruited through a community-based sentinel survey. We determined the clinical and treatment factors associated with the presence of peripheral sensory neuropathy in HIV+ subjects at baseline examination, and at 1-year follow-up. Baseline examination was assessed with a logistic regression analysis controlling for age, education level, history of drug/alcohol use, and anti-retroviral treatment. The risk of developing new peripheral neuropathy at follow-up was determined using a Cox proportional hazard model analysis. At study entry, neuropathy (n=64) was associated with acquired immunodeficiency syndrome (AIDS), nucleoside analogue reverse transcriptase inhibitors (NRTI) (i.e. ddC), and history of alcohol abuse. After 1-year follow-up, the development of neuropathy was predicted by AIDS, age (older subjects), and NRTI use. These findings indicated that AIDS, age, alcohol abuse/dependence, and anti-retroviral medication use are important predictors of motor/sensory peripheral neuropathy in the HIV infection. The peripheral neurotoxic effect of anti-retroviral medication should be taken into account in the design of long-term therapies.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acquired Immunodeficiency Syndrome / complications*
  • Acquired Immunodeficiency Syndrome / drug therapy*
  • Adult
  • Anti-Retroviral Agents / adverse effects
  • Anti-Retroviral Agents / therapeutic use*
  • Chi-Square Distribution
  • Confidence Intervals
  • Female
  • Follow-Up Studies
  • HIV Infections / complications
  • HIV Infections / drug therapy
  • Humans
  • Logistic Models
  • Male
  • Middle Aged
  • Odds Ratio
  • Peripheral Nervous System Diseases / chemically induced
  • Peripheral Nervous System Diseases / etiology*
  • Proportional Hazards Models
  • Risk Factors


  • Anti-Retroviral Agents