Mouse models of pancreatic cancer: the fur is finally flying!

Cancer Cell. 2004 Jan;5(1):7-11. doi: 10.1016/s1535-6108(03)00337-4.


Pancreatic cancer remains one of the most lethal of all human malignancies. Until recently, preclinical studies have been hampered by the absence of mouse models faithfully recapitulating critical elements of the human disease. However, recent months have witnessed a flurry of activity with respect to prospective mouse models. This progress now allows the evaluation of novel strategies for early detection, chemoprevention, and therapy and also provides new insights regarding the potential for differentiated and undifferentiated cell types to act as cells of origin for pancreatic ductal adenocarcinoma.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Anticarcinogenic Agents / pharmacology
  • Carcinogens / metabolism
  • Carcinoma, Pancreatic Ductal / drug therapy
  • Carcinoma, Pancreatic Ductal / pathology*
  • Cyclin-Dependent Kinase Inhibitor p16 / metabolism
  • Disease Models, Animal*
  • Genes, Tumor Suppressor / physiology
  • Genes, ras / physiology
  • Humans
  • Mice
  • Neoplasms, Experimental / drug therapy
  • Neoplasms, Experimental / pathology*
  • Pancreatic Ducts / pathology
  • Pancreatic Neoplasms


  • Anticarcinogenic Agents
  • Carcinogens
  • Cyclin-Dependent Kinase Inhibitor p16