Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation

EMBO J. 2004 Feb 11;23(3):483-8. doi: 10.1038/sj.emboj.7600061. Epub 2004 Jan 29.


In 1959, Dave Brubeck and Paul Desmond revolutionized modern jazz music by composing their unforgettable Take Five in 5/4, one of the most defiant time signatures in all music. Of similar revolutionary importance for biomedical and basic biochemical research is the identification of the minimal set of genes required to obtain a deadly time bomb ticking in all of us: Alzheimer's disease. It now appears that one needs to Take Five genes to produce a deadly peptide by a proteolytic mechanism, which paradoxically is otherwise of pivotal importance for development and cell fate decisions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alzheimer Disease / metabolism*
  • Amyloid Precursor Protein Secretases
  • Amyloid beta-Protein Precursor / metabolism*
  • Animals
  • Aspartic Acid Endopeptidases
  • Endopeptidases / metabolism*
  • Humans
  • Membrane Proteins / metabolism*
  • Peptide Hydrolases


  • Amyloid beta-Protein Precursor
  • Membrane Proteins
  • PSENEN protein, human
  • APH1A protein, human
  • Amyloid Precursor Protein Secretases
  • Endopeptidases
  • Peptide Hydrolases
  • Aspartic Acid Endopeptidases
  • BACE1 protein, human