Age-related changes in lymphocyte development and function

Nat Immunol. 2004 Feb;5(2):133-9. doi: 10.1038/ni1033.


The effects of aging on the immune system are widespread and extend from hematopoietic stem cells and lymphoid progenitors in the bone marrow and thymus to mature lymphocytes in secondary lymphoid organs. These changes combine to result in a diminution of immune responsiveness in the elderly. This review aims to provide an overview of age-related changes in lymphocyte development and function and discusses current controversies in the field of aging research.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Aging / immunology*
  • Aging / pathology
  • Animals
  • B-Lymphocytes / cytology
  • B-Lymphocytes / immunology
  • Cell Differentiation
  • Hematopoiesis / immunology
  • Hematopoietic Stem Cells / cytology
  • Hematopoietic Stem Cells / immunology
  • Humans
  • Immunity, Innate
  • Lymphocytes / cytology
  • Lymphocytes / immunology*
  • Mice
  • Models, Immunological
  • T-Lymphocytes / cytology
  • T-Lymphocytes / immunology