Remission of collapsing focal segmental glomerulosclerosis following chemotherapy for myeloma

Am J Kidney Dis. 2004 Feb;43(2):e10-2. doi: 10.1053/j.ajkd.2003.10.036.


Collapsing focal segmental glomerulosclerosis can be idiopathic but has been associated with human immunodeficiency virus infection as well as lymphoproliferative, myeloproliferative, and autoimmune disorders. It has a more rapid progression to end-stage renal failure. Treatment of this condition is poorly defined with no clear evidence of response to any treatment regimens. We report a case of collapsing focal segmental glomerulosclerosis in association with multiple myeloma that underwent partial remission following treatment for the underlying disease.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Dexamethasone / therapeutic use
  • Doxorubicin / therapeutic use
  • Female
  • Glomerulosclerosis, Focal Segmental / complications*
  • Glomerulosclerosis, Focal Segmental / physiopathology
  • Humans
  • Middle Aged
  • Multiple Myeloma / complications*
  • Multiple Myeloma / drug therapy*
  • Remission Induction
  • Vincristine / therapeutic use


  • Vincristine
  • Dexamethasone
  • Doxorubicin

Supplementary concepts

  • VAD I protocol