Abstract
Genomic instability is a hallmark of most human cancers including high-risk human papillomavirus (HPV)-associated anogenital neoplasia. The two HPV-encoded oncoproteins, E6 and E7, can independently induce chromosomal abnormalities. We summarize the current state of knowledge concerning HPV-induced genomic instability and discuss its significance in the context of human carcinogenesis.
Copyright 2003 Wiley-Liss, Inc.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Cell Cycle / physiology
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Chromosome Aberrations
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DNA Damage
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Female
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Genomic Instability*
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Humans
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Mitosis / physiology
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Oncogene Proteins, Viral / genetics*
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Papillomaviridae / genetics*
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Papillomaviridae / metabolism
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Papillomavirus E7 Proteins
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Papillomavirus Infections / genetics*
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Papillomavirus Infections / virology
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Repressor Proteins*
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Uterine Cervical Neoplasms / genetics*
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Uterine Cervical Neoplasms / virology
Substances
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E6 protein, Human papillomavirus type 16
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Oncogene Proteins, Viral
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Papillomavirus E7 Proteins
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Repressor Proteins
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oncogene protein E7, Human papillomavirus type 16