Mechanisms of genomic instability in human cancer: insights from studies with human papillomavirus oncoproteins

Int J Cancer. 2004 Mar 20;109(2):157-62. doi: 10.1002/ijc.11691.

Abstract

Genomic instability is a hallmark of most human cancers including high-risk human papillomavirus (HPV)-associated anogenital neoplasia. The two HPV-encoded oncoproteins, E6 and E7, can independently induce chromosomal abnormalities. We summarize the current state of knowledge concerning HPV-induced genomic instability and discuss its significance in the context of human carcinogenesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Cell Cycle / physiology
  • Chromosome Aberrations
  • DNA Damage
  • Female
  • Genomic Instability*
  • Humans
  • Mitosis / physiology
  • Oncogene Proteins, Viral / genetics*
  • Papillomaviridae / genetics*
  • Papillomaviridae / metabolism
  • Papillomavirus E7 Proteins
  • Papillomavirus Infections / genetics*
  • Papillomavirus Infections / virology
  • Repressor Proteins*
  • Uterine Cervical Neoplasms / genetics*
  • Uterine Cervical Neoplasms / virology

Substances

  • E6 protein, Human papillomavirus type 16
  • Oncogene Proteins, Viral
  • Papillomavirus E7 Proteins
  • Repressor Proteins
  • oncogene protein E7, Human papillomavirus type 16