Mutual excitation among dorsal root ganglion neurons in the rat

Neurosci Lett. 1992 Oct 26;146(1):53-6. doi: 10.1016/0304-3940(92)90170-c.


Intracellular recordings were obtained from primary sensory neurons in excised dorsal root ganglia (DRGs). Most (90%) neurons sampled became depolarized during periods of repetitive stimulation of a branch of the dorsal root (DR) which contained only axons of neighboring neurons. DR stimulation also evoked a transient rise in extracellular K+ concentration ([K+]o), following similar kinetics. Thus, the mutual excitation among DRG neurons may be mediated by [K+]o. Activity-dependent cross-excitation in DRGs could contribute to neuropathic sensory abnormalities often triggered by nerve injury or disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Ganglia, Spinal / cytology*
  • Ganglia, Spinal / physiology
  • In Vitro Techniques
  • Kinetics
  • Membrane Potentials / physiology
  • Microelectrodes
  • Myelin Sheath / physiology
  • Neurons / physiology*
  • Potassium / pharmacology
  • Rats
  • Rats, Wistar


  • Potassium