Pharmacological properties of the homomeric alpha 7 receptor

Neurosci Lett. 1992 Oct 26;146(1):87-90. doi: 10.1016/0304-3940(92)90179-b.


The pharmacological properties of the alpha-bungarotoxin sensitive alpha 7 neuronal nicotinic acetylcholine receptor (nAChR) were studied upon reconstitution in Xenopus oocytes. Channels formed by alpha 7 are about 10-fold more sensitive to nicotine and cytisine than to ACh but are little, if at all, activated by the ganglionic agonist 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP). Tubocurarine (TC) was found to act as a non-competitive inhibitor, whereas dihydro-beta-erythroidine (DH beta E) behaves as a pure competitive inhibitor whose blockade is fast and fully reversible. In addition, the alpha 7 receptor displays a poor sensitivity to methonium salts. The pharmacological properties of the alpha 7 channels are readily distinguishable from those of other identified neuronal nicotinic receptors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcholine / pharmacology
  • Alkaloids / pharmacology
  • Animals
  • Azocines
  • Dihydro-beta-Erythroidine / pharmacology
  • Dimethylphenylpiperazinium Iodide / pharmacology
  • Hexamethonium Compounds / pharmacology
  • Nicotine / pharmacology
  • Oocytes / drug effects
  • Quinolizines
  • Receptors, Cholinergic
  • Receptors, Nicotinic / drug effects*
  • Tubocurarine / pharmacology
  • Xenopus


  • Alkaloids
  • Azocines
  • Hexamethonium Compounds
  • Quinolizines
  • Receptors, Cholinergic
  • Receptors, Nicotinic
  • Dihydro-beta-Erythroidine
  • cytisine
  • Dimethylphenylpiperazinium Iodide
  • Nicotine
  • Acetylcholine
  • Tubocurarine