Abstract
Several 2,3-diaryl-1,3-thiazolidin-4-ones were synthesized and evaluated as anti-HIV agents. The results of the in vitro tests showed that some of them were highly effective inhibitors of HIV-1 replication at 30-50 nM concentrations with minimal cytotoxicity, thereby acting as non-nucleoside HIV-1 reverse transcriptase inhibitors (NNRTIs).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-HIV Agents / chemical synthesis*
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Anti-HIV Agents / pharmacology*
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Cell Survival / drug effects
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Cell Survival / physiology
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Drug Evaluation, Preclinical
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HIV-1 / drug effects
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HIV-1 / growth & development
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HIV-2 / drug effects
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HIV-2 / growth & development
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Humans
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Molecular Structure
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Reverse Transcriptase Inhibitors / chemical synthesis*
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Reverse Transcriptase Inhibitors / pharmacology*
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Structure-Activity Relationship
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T-Lymphocytes / drug effects
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T-Lymphocytes / virology
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Thiazoles / chemical synthesis*
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Thiazoles / pharmacology*
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Virus Replication / drug effects
Substances
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Anti-HIV Agents
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Reverse Transcriptase Inhibitors
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Thiazoles