Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis

Pharmacol Biochem Behav. 2004 Feb;77(2):399-404. doi: 10.1016/j.pbb.2003.12.003.

Abstract

We have recently reported the presence of the anxiolytic flavone 6-methylapigenin (MA) and of the sedative and sleep-enhancing flavanone glycoside 2S (-) hesperidin (HN) in Valeriana officinalis and Valeriana wallichii. MA, in turn, was able to potentiate the sleep-inducing properties of HN. The present paper reports the identification in V. officinalis of the flavone glycoside linarin (LN) and the discovery that it has, like HN, sedative and sleep-enhancing properties that are potentiated by simultaneous administration of valerenic acid (VA). These effects should be taken into account when considering the pharmacological actions of valeriana extracts.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Binding, Competitive / drug effects
  • Cerebral Cortex / drug effects
  • Cerebral Cortex / metabolism
  • Drug Synergism
  • Flunitrazepam / pharmacokinetics
  • GABA Modulators / pharmacokinetics
  • Glycosides / isolation & purification
  • Glycosides / pharmacology*
  • Hypnotics and Sedatives*
  • Indenes / isolation & purification
  • Indenes / pharmacology
  • Magnetic Resonance Spectroscopy
  • Male
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Rats
  • Rats, Wistar
  • Sesquiterpenes / isolation & purification
  • Sesquiterpenes / pharmacology
  • Sleep / drug effects*
  • Spectrophotometry, Ultraviolet
  • Synaptosomes / drug effects
  • Synaptosomes / metabolism
  • Thiopental / pharmacology
  • Valerian / chemistry*

Substances

  • GABA Modulators
  • Glycosides
  • Hypnotics and Sedatives
  • Indenes
  • Plant Extracts
  • Sesquiterpenes
  • valerenic acid
  • Flunitrazepam
  • linarin
  • Thiopental