Solitary cerebellar metastasis of malignant pleural mesothelioma: case report

Surg Neurol. 2004 Feb;61(2):174-8; discussion 178-9. doi: 10.1016/s0090-3019(03)00448-8.


Background: Malignant pleural mesothelioma is an uncommon malignancy that rarely metastasizes to the central nervous system and even less frequently occurs as a solitary lesion.

Case description: We present a 71-year-old white female, nonsmoker, with no occupational exposure to asbestos. She presented with a 15-lb. weight loss over several months and persistent right subscapular pain radiating to her anterior chest. Imaging studies revealed a pleural mass, and biopsy confirmed fibrous type malignant pleural mesothelioma. During a metastatic workup, computed tomography (CT) and magnetic resonance imaging (MRI) of the head demonstrated a 1 cm subcortical, contrast-enhancing lesion without surrounding edema in the right posterior cerebellum. Surgical resection of the solitary cerebellar mass revealed fibrous-type metastatic malignant mesothelioma. Postoperatively, the patient received a combined chemotherapy regimen of Adriamycin and Cisplatin and underwent whole brain radiation therapy.

Conclusions: We report the first resection of a solitary cerebellar metastasis of malignant pleural mesothelioma. We also review past cases of intracranial metastasis of this malignancy, its histologic subtypes, outcome, and recent treatment modalities.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Cerebellar Neoplasms / diagnosis
  • Cerebellar Neoplasms / secondary*
  • Cerebellar Neoplasms / surgery
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Mesothelioma / diagnosis
  • Mesothelioma / secondary*
  • Mesothelioma / surgery
  • Neurosurgical Procedures / methods
  • Pleural Effusion, Malignant / diagnosis*
  • Pleural Neoplasms / pathology*
  • Pleural Neoplasms / surgery