GENIUS II: a high-throughput database system for linking ORFs in complete genomes to known protein three-dimensional structures

Bioinformatics. 2004 Mar 1;20(4):596-8. doi: 10.1093/bioinformatics/btg478. Epub 2004 Jan 29.

Abstract

GENIUS II is an automated database system in which open reading frames (ORFs) in complete genomes are assigned to known protein three-dimensional (3D) structures. The system uses the multiple intermediate sequence search method in which query and target sequences are linked by intermediate sequences gathered by PSI-BLAST search. By applying the system to 129 complete genomes, 43.8% on average of the ORFs in the genomes were assigned to known 3D structures and the results are available for free at GENIUS II web site.

MeSH terms

  • Algorithms
  • Amino Acid Sequence
  • Database Management Systems*
  • Databases, Protein*
  • Genome*
  • Information Storage and Retrieval / methods*
  • Molecular Sequence Data
  • Open Reading Frames / genetics*
  • Protein Conformation
  • Proteins / analysis
  • Proteins / chemistry*
  • Proteins / genetics*
  • Sequence Alignment / methods*
  • Sequence Analysis, Protein / methods*
  • Statistics as Topic

Substances

  • Proteins